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HESI RN · HESI Pharmacology · Pharmacology CNS Drugs Quizlet

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

Which of the following mechanisms of action most likely contributes to the treatment of parkinsonism?

A. The direct-acting dopaminergic agonist amantadine mimics the activity of striatal dopamine

B. The antimuscarinic activity of diphenhydramine contributes to the restoration of striatal dopaminergic-cholinergic neurotransmitter balance

C. Striatal H1-receptors are blocked by the antihistaminic trihexyphenidyl

D. The ergoline bromocriptine stimulates the release of striatal dopamine from intact terminals

Expert Explanatory Rationale

Correct Answer: The antimuscarinic activity of diphenhydramine contributes to the restoration of striatal dopaminergic-cholinergic neurotransmitter balance

Question 2 of 5

A young boy who has been treated for epilepsy for a year is referred to a dentist for evaluation of massive overgrowth of his gingival tissue. Which of the following drugs was the most likely cause of the oral pathology?

A. Lamotrigine

B. Lorazepam

C. Phenobarbital

D. Phenytoin

Expert Explanatory Rationale

Correct Answer: Phenytoin

Question 3 of 5

Infusion of phentolamine into the cerebrospinal fluid of an experimental animal will prevent the blood pressure-lowering action of

A. Clonidine

B. Enalapril

C. Guanethidine

D. Reserpine

Expert Explanatory Rationale

Correct Answer: Clonidine

Question 4 of 5

Which of the following benzodiazepines has the shortest half-life?

A. Clonazepam

B. Oxazepam

C. Midazolam

D. None of the above

Expert Explanatory Rationale

Correct Answer: None of the above

Question 5 of 5

Which of the following is a prodrug of adrenaline used topically in glaucoma?

A. Phenylephrine

B. Dipivefrine

C. Phenylpropanolamine

D. Dorzolamide

Expert Explanatory Rationale

Correct Answer: Dipivefrine

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