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HESI RN · HESI Pharmacology · Drugs immune system

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

Select the antibiotic whose dose must be reduced in patients with renal insufficiency

A. Ampicillin

B. Chloramphenicol

C. Tobramycin

D. Erythromycin

Correct Answer: Tobramycin

Question 2 of 5

Benzathine penicillin injected once every 4 weeks for 5 years or more is the drug of choice for

A. Agranulocytosis patients

B. Prophylaxis of bacterial endocarditis in patients with valvular defects

C. Prophylaxis of rheumatic fever

D. Treatment of anthrax

Correct Answer: Prophylaxis of rheumatic fever

Question 3 of 5

Gram-negative organisms are largely insensitive to benzyl penicillin because

A. They produce large quantities of penicillinase

B. They do not utilize D-alanine whose incorporation in the cell wall is inhibited by benzyl penicillin

C. Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria

D. Both (a) and (b)

Correct Answer: Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria

Question 4 of 5

Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromycin is that

A. Eradicates mycoplasmal infections in a single dose

B. Is active against strains of streptococci that are resistant to erythromycin

C. Is more active against Mycobacterium avium complex

D. Does not inhibit live drug-metabolizing enzymes

Correct Answer: Is more active against Mycobacterium avium complex

Question 5 of 5

Tetracyclines are still the first choice drugs for the following disease.

A. Granuloma inguinale

B. Chancroid

C. Syphilis

D. Gonorrhoea in patients allergic to penicillin

Correct Answer: Granuloma inguinale

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