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HESI RN · HESI Pharmacology · Chemotherapy drugs

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

Precautions to reduce crystalluria during sulphonamides use is:

A. Acidification of urine
B. Reduced fluid intake
C. Alkalinization of urine
D. Increase dose

Expert Explanatory Rationale

Correct Answer: Alkalinization of urine

Question 2 of 5

The mechanism of antibacterial action of cephalosporins involves:

A. Inhibition of synthesis of precursors of peptidoglycans.
B. Interference with the synthesis of ergosterol.
C. Inhibition of transpeptidation reaction in cell wall synthesis
D. Inhibition of beta-lactamases.

Expert Explanatory Rationale

Correct Answer: Inhibition of transpeptidation reaction in cell wall synthesis

Question 3 of 5

All the following antifungal drugs are antibiotics, EXCEPT:

A. Amphotericin B
B. Nystatin
C. Miconazol
D. Griseofulvin

Expert Explanatory Rationale

Correct Answer: Miconazol

Question 4 of 5

A 42-year-old man with a history of recurrent mycoplasma pulmonary infections presents with similar complaints. Sputum culture reveals that the organism present demonstrates resistance to erythromycin and the macrolide antibiotic class. What is the most likely explanation for this finding?

A. Ability of the organism to take up the antibiotic
B. Improved affinity of the 50S ribosome for the antibiotic
C. Plasmid-associated erythromycin esterase
D. Presence of an influx pump

Expert Explanatory Rationale

Correct Answer: Plasmid-associated erythromycin esterase

Question 5 of 5

A 24-year-old man with Hodgkin’s lymphoma presents to the emergency department with chest pain for the past 2 days. An electrocardiogram shows nonspecific changes. An echocardiogram is performed that shows dilation of the left ventricle, and the diagnosis of dilated cardiomyopathy is made. He has been receiving chemotherapy for Hodgkin’s lymphoma over the last month. What medication is most likely responsible for his cardiomyopathy?

A. Bleomycin
B. Cisplatin
C. Dactinomycin
D. Doxorubicin

Expert Explanatory Rationale

Correct Answer: Doxorubicin

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