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HESI RN · HESI Pharmacology · Chapter 26 principles of pharmacology

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

All of the following statements about plasma protein binding of a drug are true except

A. Displacement of a drug from plasma protein binding sites results in a transient increased volume of distribution (V_D)

B. Displacement of a drug from plasma protein binding sites makes more free drug available for glomerular filtration

C. Displacement of a potent drug that is normally more than 95% bound may cause toxicity

D. Drugs that are highly bound to plasma proteins generally have a greater V_D compared with drugs that are highly bound to tissue proteins

Expert Explanatory Rationale

Correct Answer: Drugs that are highly bound to plasma proteins generally have a greater V_D compared with drugs that are highly bound to tissue proteins

Question 2 of 5

A medical student is involved in a summer research project evaluating the excitatory and inhibitory effects of five neurotransmitters. Following as choices are the five neurotransmitters and their excitatory and inhibitory status. Which of the following neurotransmitters is likely to be serotonin?

A. Neurotransmitter A; excitatory

B. Neurotransmitter B; excitatory

C. Neurotransmitter C; excitatory and inhibitory

D. Neurotransmitter D; inhibitory

Expert Explanatory Rationale

Correct Answer: Neurotransmitter C; excitatory and inhibitory

Question 3 of 5

Phenylephrine causes

A. Constriction of vessels in the nasal mucosa

B. Increased gastric secretion and motility

C. Increased skin temperature

D. Miosis

Expert Explanatory Rationale

Correct Answer: Constriction of vessels in the nasal mucosa

Question 4 of 5

Precipitation may occur when mixing aqueous solutions of meperidine hydrochloride with which of the following solutions?

A. Sodium bicarbonate injection

B. Atropine sulfate injection

C. Sodium chloride injection

D. None listed

Expert Explanatory Rationale

Correct Answer: Sodium bicarbonate injection

Question 5 of 5

Ribavirin:

A. Is indicated in CMV retinitis in AIDS patients

B. Inhibits viral RNA methyltransferase

C. Must be taken up into cells and phosphorylated to be effective

D. Can be administered via aerosol inhalation to treat bronchiolitis

Expert Explanatory Rationale

Correct Answer: Must be taken up into cells and phosphorylated to be effective

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