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HESI RN · HESI Pharmacology · Chapter 11 principles of pharmacology

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

A 48-year-old-man with end-stage liver disease is hospitalized on the intensive care unit. Review of his blood work reveals elevated liver function tests to five times the normal rate. The patient is receiving multiple intravenous medications. Which of the following medications is likely to be therapeutic for this patient?

A. Epinephrine

B. Erythromycin

C. Nifedipine

D. Rifampin

Expert Explanatory Rationale

Correct Answer: Epinephrine

Question 2 of 5

Concerning paracetamol, all are true Except:

A. Preferred to aspirin in peptic ulcer.

B. Acute paracetamol poisoning causes hepatic damage.

C. Interferes with excretion of uric acid.

D. May be used intravenously in acute fever of infectious origin.

Expert Explanatory Rationale

Correct Answer: Interferes with excretion of uric acid.

Question 3 of 5

Terbinafine:

A. Is indicated in dermatophyte nail infections

B. A topical preparation is indicated in ringworm infection (e.g. tinea pedis/cruris)

C. A single dose is usually effective

D. Is a potent CYP450 enzyme inducer

Expert Explanatory Rationale

Correct Answer: Is indicated in dermatophyte nail infections

Question 4 of 5

Which of the following most accurately describes the transmembrane signaling process involved in steroid hormone action?

A. Action on a membrane spanning tyrosine kinase

B. Activation of a G protein which activates or inhibits adenyl cyclase

C. Diffusion into the cytoplasm and binding to an intracellular receptor

D. Diffusion of 'STAT' molecules across the membrane

Expert Explanatory Rationale

Correct Answer: Diffusion into the cytoplasm and binding to an intracellular receptor

Question 5 of 5

Drug that show nonlinear pharmacokinetics have which property?

A. A constant ratio of drug metabolites is formed as the administered dose increases

B. The elimination half-life (t_Ãƒâ€šÃ‚Â½) increases as the administered dose increases

C. The area under the plasma drug concentration versus time curve (AUC) increases in direct proportion to an increase in the administered dose

D. Both low and high doses follow first-order elimination kinetics

Expert Explanatory Rationale

Correct Answer: The elimination half-life (t_Ãƒâ€šÃ‚Â½) increases as the administered dose increases

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