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HESI LPN · HESI LPN Pharmacology · HESI Principles of Pharmacology

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

A 17-year-old boy drank increasing amounts of alcohol when attending parties. He noticed that lately he was able to better tolerate alcohol effects and asked his physician the reason for this. The physician said that pharmacodynamic tolerance had probably occurred. Which of the following actions most likely mediated this tolerance?

A. Decreased concentration of the drug at the site of action

B. Homeostatic adaptive changes that counteract the drug effect

C. Decreased bioavailability of the drug

D. Increased biotransformation of the drug

Expert Explanatory Rationale

Correct Answer: Homeostatic adaptive changes that counteract the drug effect

Question 2 of 5

Drugs that use CYP 3A4 isoenzymes for metabolism may:

A. Induce the metabolism of another drug

B. Inhibit the metabolism of another drug

C. Both A and B

D. Neither A nor B

Expert Explanatory Rationale

Correct Answer: Both A and B

Question 3 of 5

A new drug was tested in an in vitro system. It was found that only one enantiomer of the racemic pair bound substantially to a specific receptor, whereas the other enantiomer showed negligible binding. Which of the following terms best defines this property?

A. Intrinsic activity

B. Affinity

C. Stereoselectivity

D. Potency

Expert Explanatory Rationale

Correct Answer: Stereoselectivity

Question 4 of 5

The foundation of clinical trials, Good Clinical Practice, is a helpful resource for nurses. The nurse is correct in choosing Good Clinical Practice as a reference for standards in which areas? (Select all that apply.)

A. Design

B. Monitoring and auditing

C. Analyses

D. Reporting

Expert Explanatory Rationale

Correct Answer: Design

Question 5 of 5

When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:

A. The sum of the effects of each drug individually

B. Greater than the sum of the effects of each drug individually

C. Less than the effect of each drug individually

D. Not predictable

Expert Explanatory Rationale

Correct Answer: Greater than the sum of the effects of each drug individually

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