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HESI LPN · HESI LPN Pharmacology · HESI Drugs immune system

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Showing all 5 practice questions with expert explanatory rationales.

Question 1 of 5

Regarding the recently introduced lipid formulation of amphotericin B, which one of the following statements is accurate?

A. Affinity of amphotericin B for these lipids is greater than affinity for ergosterol

B. They are less expensive to use than conventional amphotericin B

C. They are more effective in fungal infections because they increase tissue uptake of amphotericin B

D. They may decrease nephrotoxicity of amphotericin B

Correct Answer: They may decrease nephrotoxicity of amphotericin B

Question 2 of 5

All of the following factors may increase the risk of nephrotoxicity from gentamicin therapy except

A. age over 70 years

B. prolonged courses of gentamicin therapy

C. concurrent amphotericin B therapy

D. trough gentamicin levels below 2 mg/ml

Correct Answer: trough gentamicin levels below 2 mg/ml

Question 3 of 5

Penicillins should not be given by

A. Intramuscular route

B. Intravenous route

C. Intrathecal route

D. Intra-articular route

Correct Answer: Intrathecal route

Question 4 of 5

The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is

A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme

B. Mutational acquisition of aminoglycoside hydrolyzing enzyme

C. Mutation reducing affinity of ribosomal protein for the antibiotic

D. Mutational loss of porin channels

Correct Answer: Plasmid mediated acquisition of aminoglycoside conjugating enzyme

Question 5 of 5

The antibiotic that enters brain freely is

A. Tetracycline

B. Erythromycin

C. Chloramphenicol

D. Gentamicin

Correct Answer: Chloramphenicol

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